Since the Ames study (OECD 471) is not recommended for Nanomaterials, Genotoxicity/Mutagenicity shall be evaluated using one or more in vitro studies on mammalian cells:
1. OECD 473: In Vitro Mammalian Chromosome Aberration Test
2. OECD 487: In Vitro Mammalian Cell Micronucleus Test
3. OECD 490: In Vitro Mammalian Cell Gene Mutation Test: Mouse Lymphoma Assay
4. OECD 476: Hypoxanthine-guanine phosphoribosyl transferase Test: HPRT Test