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LAUS testing ABC: M for “Moly” and “Micronucleus”

The Mouse Lymphoma Assay acc. to OECD 490 (short “Moly”) and the Micronucleus Assay acc. to OECD 487 are both in vitro studies to evaluate the mutagenicity/genotoxicity induced by chemical substances.

OECD 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene

  • detection of gene mutations
  • test system: mouse lymphocytes (L5178Y TK+/- clone (3.7.2C))

OECD 487: In Vitro Mammalian Cell Micronucleus Test

  • detection of micronuclei in the cytoplasm of interphase cells
  • test system: human lymphocytes freshly obtained by venipuncture

We have increased our capacities and can offer good timelines!

#LAUSgroup #mutagenicity #Moly #Micronucleus


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