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OECD 497 provides Defined Approaches (DAs) on Skin Sensitisation

OECD 497 provides Defined Approaches (DAs) for Skin Sensitisation assessment. It allows the Hazard Potential Identification (skin sensitiser / non-sensitiser) and GHS Classification into Potency subcategories 1A and 1B (H317) without animal tests.

Multiple information sources are taken into consideration to come to a conclusion:

In chemico test data (OECD 442C DPRA)

In vitro study data (OECD 442D KeratinoSens, OECD 442E h-CLAT)

In silico predictions (QSAR, DEREK Nexus)


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#LAUSgroup #OECD497 #invitrosensitisation #animalfree #NAM #skinsensitisation #H317

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