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Pesticides and Plant Protection Products

LAUS is your partner when it comes to GLP studies for the registration of new pesticides or the re-registration of already registered plant protection products. Due to our wide range of analytical equipment, we can develop and validate a specific analytical method for your AS (active substance) in formulations with various matrices. We can determine the AS content and support you with ILV studies (Independent Laboratory Validation). With the newest technology we are able to provide the lowest achievable LOQs (Limit of Quantification) for residue studies regarding the MRL (Maximum Residue Level).
In addition LAUS can support you with Stability Studies in combination with analytical and physico-chemical parameters. We determine endpoints in the area of toxicology, ecotoxicology, e-fate, and mutagenicity.

Analytical Chemistry

Development and Validation of Analytical Methods

acc. to SANTE/2020/12830, Rev.1

Residue Studies

according to SANTE/2020/12830, Rev.1
and OECD 506: Stability of Pesticide Residues in Stored Commodities

Stability Studies

Accelerated Storage Stability; CIPAC MT 46
Stability of liquid formulations at 0°C, CIPAC MT 39:
- Low temperature stability, emulsifiable concentrates and solutions (MT 39.1) aqueous solutions (MT 39.2) liquid formulations (MT 39.3)
Long Term Stability (Shelf Life Stability)
- Stability according Technical Monograph n°17, 2nd Edition, 2 years at ambient temperature

5-Batch Analyses (Active Ingredient and Impurities)

according to SANCO 3030/99

ILV Studies (Independent Laboratory Validation)

according to SANTE/2020/12830, Rev.1

Other Endpoints

Physico-chemical Properties

CIPAC, EU and OECD methods

In vitro / in vivo Toxicology

Skin/eye irritation/corrosion, oral/dermal toxicity

Aquatic and Terrestrial Ecotoxicology

Environmental Fate

Mutagenicity / Genotoxicity

Endocrine Properties

Regulation (EU) 1107/2009 and legal Background

Most pesticides serve as PPP (Plant Protection Products). They protect plants or crops against pest or plant diseases and are grouped by the organism they are meant to protect plants from: herbicides, insecticides, fungicides, bactericides, nematicides, and many more.

In the EU (European Union), Regulation (EU) 1107/2009 sets the requirements for the authorization of PPPs.

In a first step the AS (Active Substance) needs to be approved for the EU. The EC (European Commission) evaluates the AS for safety regarding human health and the environment. The MRL (Maximum Residue Level) will be determined in accordance with Regulation (EC) No 396/2005 for food and feed, when pesticides are applied according to Good Agricultural Practice. The approval is followed by the authorization of the PPPs in the individual member states. In the EU the responsible authorities are the EC, EFSA (European Food Safety Authority), and ECHA (European Chemicals Agency).

In the US (United Sates of America), the EPA (Environmental Protection Agency) is the responsible authority for regulating pesticides under the FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act) and the FQPA (Food Quality Protection Act). The USDA (United States Department of Agriculture) and the FDA (United States Food and Drug Administration) set standards for the allowed level of pesticide residue in crops.

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