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Terrestrial ecotoxicity studies of substances are of great importance because effects on target as well as on non-target organisms in the environmental compartment `soil` can be analysed and evaluated.

In the field of terrestrial toxicity LAUS covers:

• OECD 207: Earthworm: Acute Toxicity Tests (Eisenia andrei)
• OECD 222: Earthworm Reproduction Test (Eisenia andrei)
• OECD 225: Sediment-Water Lumbriculus Toxicity Test Using Spiked Sediment
• OECD 218: Sediment-Water Chironomid Toxicity Test Using Spiked Sediment
• OECD 219: Sediment-Water Chironomid Toxicity Test Using Spiked Water
• OECD 216: Soil Microorganisms: Nitrogen Transformation Test
• OECD 217: Soil Microorganisms: Carbon Transformation Test

#LAUSgroup #ERA #EMA #pharmaceuticals #REACH

LAUS offers all required studies that lead to the appropriate classification according to German federal water act (AwSV), April 18, 2017:

• Acute toxicity on algae, Daphnia, (fish)
• Biodegradability
• Bioaccumulation potential logPOW
• Water solubility

#LAUS group #WGK #Waterhazard

https://www.laus.group/en/product-groups/classification-of-water-hazard

Detergents, home care and industrial & institutional cleaning products require testing to ensure the safety of the environment and human health. There are different frameworks to comply with:

• Regulation (EC) No 648/2004 on detergents
• EU Ecolabel
• Wasch- und Reinigungsmittelgesetz
• EPA’s Safer Choice Program / CleanGredients

LAUS offers the required experimental endpoints:

• Ready Biodegradability
• Aquatic studies
• In vitro Eye and Skin testing
• Mutagenicity

#LAUSgroup #EUecolabel #SaferChoice #Detergents

We have doubled our capacities for Ready Biodegradability testing to be able to offer better timelines despite the high demand we are currently experiencing. In the picture you see the brand new Oxitop respirometers for electronically monitoring the Biochemical Oxygen Demand (BOD) during the aerobic biodegradability study according to OECD 301F.

We test:

• Cosmetic products and ingredients
• Detergents, cleaning and laundry products
• Chemicals
• For Water Hazard Classification
• Polymers
• Lubricants
• And many more

The European Commission has revised the information requirements for registering chemicals under REACH. Changes will start to apply 8 January 2022:

Commission Regulation (EU) 2021/979 of 17 June 2021 amending Annexes VII to XI to Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)

https://eur-lex.europa.eu/legal-content/EN/ALL/?uri=CELEX:32021R0979

For China REACH, MEE Order No.12 brings three main changes in the data requirements:

• Physico-chemical test data from non-Chinese laboratories are accepted
• In-vitro skin and eye irritation studies are accepted if the results are conclusive
• Additional requirements based on P and B potential (Persistence and Bioaccumulation), e.g. toxicological data, sediment chironomid test, etc.

Click here for more information.

LAUS could support you with studies simulating physiological conditions in the gastrointestinal tract after food consumption required by EFSA for Nanomaterials in food. A short simulation of mouth conditions, followed by a gastric phase at a pH of 3 for 2 h and an intestinal phase at a pH of 7 for 2 h in a static set-up provides information for the “risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain” (EFSA Journal 2018;16(7):5327).

Currently we are working on dynamic/flow studies to complement these studies.

#LAUSGmbH #invitrodigestion #bioaccessability #nanomaterials