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04.01.2023

OECD 497: Defined Approaches (DAs) on Skin Sensitisation

OECD 497 provides Defined Approaches (DAs) for Skin Sensitisation assessment. It allows the Hazard Potential Identification (skin sensitiser / non-sensitiser) and GHS Classification into Potency subcategories 1A and 1B (H317) without animal tests.

Multiple information sources are taken into consideration to come to a conclusion:

In chemico test data (OECD 442C DPRA)

In vitro study data (OECD 442D KeratinoSens, OECD 442E h-CLAT)

In silico predictions (QSAR, DEREK Nexus)

Literature

Contact us for more information!

https://www.laus.group/en/performance-profile/toxicology/in-vitro-toxikologie

#LAUSgroup #OECD497 #invitrosensitisation #animalfree #NAM #skinsensitisation #H317

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04.01.2023

Health and Happyness for 2023!

An Automated External Defibrillator(AED) can save lives and it is much easier to use than you would expect. Since this is a matter close to our heart, in the context of the biannual safety check we had a briefing and demonstration of LAUS’ AED. Not only First Aiders could participate, but everyone interested was welcome to see how easy it could be operated. Luckily we yet have not had a situation where we needed it, but this training will hopefully encourage people to act where needed.

We hope you had a good start into the New Year and in this context we wish you Health and Happiness for 2023!

#LAUSgroup #AED #HappyNewYear

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07.12.2022

Viscosity of Newtonian and Non-Newtonian fluids

For the determination of the viscosity of liquids acc. to OECD 114 we now have two options:

- falling sphere viscometer (acc. to Höppler) in a range between 0,6 – 70.000 mPa*s and

- rotational viscometer in a range between 3 – 1.000.000 mPa*s

This allows us to test Newtonian as well as Non-Newtonian fluids regarding dynamic viscosity and calculate the kinematic viscosity.

#LAUSgroup #viscosity #newtonianfluid #nonnewtonianfluid #GLP

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24.11.2022

New requirements for corrosion to metals testing on biocides

TAB APCP ver 3.0 states that testing on corrosion to metals shall follow the UN Test C.1 AND it must be guaranteed that the content of the active substance throughout the test is kept stable, thus the composition should be checked/analysed throughout the test or at least at the end of the test.

If you are affected, contact us to discuss an individual strategy for testing your biocidal product.

Technical Agreements for Biocides

Analytical Methods, PhysicoChemical Properties and Physical Hazards (APCP)

Version 3.0, September 2022

#LAUSgroup #biocides #metalcorrosion

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08.11.2022

Deadline for product authorization of DDAC in PT 1 and PT2

The deadline for applying for product authorization for the active substance DDAC in biocidal products of PT 1 and 2 is 01 February 2024. Good to know that LAUS has already experience with the analytical determination of quaternary ammonium compounds like DDAC. Contact us for more information.

https://www.laus.group/en/product-groups/biocides

#LAUSgroup #BPR #QUATs #DDAC

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18.10.2022

You want to establish a new supply chain and need a Sameness analysis for REACH?

Due to the geopolitical situation there are numerous bottlenecks in the supply chains of many companies. If you have identified a new, alternative supplier for your chemical, who has not imported into the EU yet, you need to make sure that you act in compliance with the EU chemicals regulation, REACH. You will need a Sameness analysis to proof the substance identity of the chemical to include your supplier in the respective REACH dossier. LAUS has extensive experience with Sameness analyses and could deliver reports within a few weeks’ time.

https://www.laus.group/en/product-groups/chemicals/sameness-reach

#LAUSgroup #supplychain #supplier #sameness

issolution #metal #metalcompounds

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18.10.2022

Transformation Dissolution Testing acc. to OECD GD 29 (T/D)

The rate and extent to which metals and sparingly soluble metal compounds can produce soluble available ionic and other metal-bearing species in aqueous media is determined in the Transformation/Dissolution study under a set of standard laboratory conditions. LAUS has many years of experience with the performance of this study according to OECD GD 29 under GLP. Contact us for more information!

#LAUSgroup #TransDis #T/D #TransformationDissolution #metal #metalcompounds

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22.09.2022

Our „Travel Gas Cylinder” picks up your sample

Clients who need analyses or experimental endpoints of a gaseous substance often have a problem with sample shipment. LAUS now has a „Travel Gas Cylinder”. This container can be shipped to pick-up your sample and has two major advantages:

  • It has a good size for a reasonable amount of sample.
  • It is equipped with the exact valve we can use in our system.

Talk to us if you are planning to test a gas, and we could discuss the requirements!

#LAUSgroup #gas #testing

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01.09.2022

FTIR with database search

The Fourier Transform Infrared Spectroscopy (FTIR) spectrum of a polymer is like a fingerprint and allows its identification.

The ATR (Attenuated total reflection) method enables us to analyse all kinds of polymers (solid, powder, films, granules, soluble, etc.) directly or after grinding. The FTIR spectrum collected in the wavenumber range 500cm-1-4000cm-1 will be compared with our polymer data base containing more than 10.000 spectra. The best matches are being reported.

Results could be used for

  • Safety Data Sheets
  • REACH Substance Identification

#LAUSgroup # FTIR #polymerdatabase

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16.08.2022

We love challenges!

LAUS is specialized in Substance Identities for substances of any kind:

  • Organic mono-constituents
  • Inorganic salts, oxides, alloys, elements
  • Gases
  • Organic multi-constituents
  • Pigments/dyes
  • UVCBs (unknown or variable composition, complex reaction products or biological materials)
  • Reaction masses
  • Mixtures
  • Waxes and oils
  • Nanomaterials

Contact us today for a tailor-made quotation!

#LAUSgroup ‘REACH # SubstanceIdentity #Sameness

https://www.laus.group/en/product-groups/chemicals/sameness-reach

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16.08.2022

Lubricants Testing

LAUS – The GLP Lab - offers testing of lubricants, additives and other components:

- Biodegradability as a contribution to Sustainability

- REACH obligations

- CLP and ADR, classification and labelling

- Water Hazard Classes (“WGK”)

Visit us at this year’s Lubricant Expo: 6 - 8 Sept. 2022, Messe Essen, Germany, Hall 7, Booth 637 or our website: https://buff.ly/3T4EUAq

#LAUSgroup #lubricants

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16.08.2022

Lubricants Expo

LAUS – The GLP Lab - will be exhibiting at this year’s Lubricant Expo: 6 - 8 Sept. 2022, Messe Essen, Germany, Hall 7, Booth 637.

Whether you need GLP studies for regulatory purposes or non-GLP studies for R&D or marketing purposes, we are your trusted partner.

Looking forward to meeting you!

Your LAUS team

#LAUSgroup #lubricants #lubricantsexpo

https://buff.ly/3dzM7rV

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16.08.2022

Particle Size Distribution

Why can the determination of the Particle Size Distribution (PSD) be challenging?

The PSD is required for a number of regulatory purposes:

  • granulometry for the REACH dossier of solid substances (OECD 110)
  • REACH substance identity profile (sameness) for Nanomaterials
  • the definition of nanoforms
  • analytical determination of nano materials in genotoxicity or ecotoxicological studies

The smaller the particles are, the more elaborate the techniques have to be. LAUS has equipped a new lab with state-of-the-art technology and trained a highly qualified study director. We have developed a deeper understanding on how to approach the different substance types (e. g. nanomaterials) and how to receive comprehensive results. Sometimes complementary techniques like SEM/TEM, XRD with Rietveld or BET are required to describe a substance in its entity.

Contact us for more information.

https://www.laus.group/en/physico-chemical-properties/oecd-eu-methoden/oecd-110-psd

#LAUSgroup #particlesizedistribution #PSD #DLS

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16.08.2022

Food Contact Materials

For Plastic Food Contact Materials EFSA requires genotoxicity testing including a minimum of two in vitro studies:

i) A bacterial reverse mutation test

ii) An in vitro mammalian cell micronucleus test

In a first step the specific migration limits (SML) expressed in mg of substance per kg of food (mg/kg) needs to be determined for the packaging material. If the exposure through migration is low, this limited data set might be sufficient. If the exposure is higher, a strategy with more toxicological information will be required.

Contact us if you want to learn more.

#FoodContactMaterial #genotoxicity

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