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Product Groups
- Chemicals
  EU REACH
  
  Sameness REACH
  
  Nanomaterials
  
  Lubricants and Additives
  
  Classification of Water Hazard
  
  GHS / CLP / ADR
  
  Polymers
  
  TSCA
  
  China REACH
  
  Korea REACH
  
  Türkiye REACH
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  Biodegradation
  
  Environmental Fate
- Biocides
  
  Whether you want to approve a new active substance or register your biocidal product, LAUS supports you with the information requirements of the Biocidal Products Regulation.
  
  We have extensive experience and offer customized test strategies for biocides that are difficult to test, such as in situ generated active substances.
  
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- Plant Protection Products
  
  For the approval of an active substance or the authorization of a plant protection product under Regulation (EU) 1107/2009, LAUS can support you with state-of-the-art analytical methods, stability studies and other endpoints for safety assessment for human health and the environment.
  
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- Personal Care
  
  For the safety assessment of Cosmetics, Personal Care Products (rinse-off or leave-on) and their Ingredients, LAUS could support you with non-animal alternative methods (NAMs), in vitro genotoxicity and biodegradability testing as well as physico-chemical properties.
  
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- Detergents
  
  LAUS tests your surfactants, detergents, washing and cleaning products in the area of ecotoxicology and environmental behavior as well as human health for regulatory purposes. We also offer biodegradability studies for ecolabels and sustainability certifications.
  
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- Human Medicinal Products
  
  In the area of Human Medicinal Products LAUS offers genotoxicity testing for pharmaceuticals in the preclinical phase and for impurities of pharmaceuticals. We can also support you with experimental data for your Environmental Risk Assessment (ERA). All studies will be performed according to the principles of Good Laboratory Practice (GLP).
  
  Human Medicinal Products - Genotoxicity Environmental Risk Assessment ERA
- Veterinary Medicinal Products
  
  For the registration of your veterinary medicinal products LAUS can support you with experimental endpoints for the environmental risk assessment (ERA). We offer studies for Phase II Tier A as well as Phase II Tier B.
  
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- Food
  
  In the food sector, LAUS offers a wide range of tests in accordance with EFSA specifications. Examples include genotoxicity tests on nanomaterials and novel foods or the in vitro simulation of the physiological conditions in the gastrointestinal tract.
  
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- FFDCA | FIFRA | TSCA
  
  LAUS GLP studies are also recognized by the EPA (United States Environmental Protection Agency) for testing requirements under TSCA (Toxic Substances Control Act), FIFRA (Federal Insecticide, Fungicide and Rodenticide Act) and FFDCA (Federal Food, Drug, and Cosmetic Act). Find our services here.
  
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Services
- Physical Chemistry
  
  LAUS offers a broad spectrum of physico-chemical studies for either the characterization of your substances or determination of safety-relevant data. We work according to OECD, EU, UN CIPAC and other common standards that are internationally recognized. Performance with and without GLP is possible.
  
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- In vitro Toxicology
  
  In the field of New Approach Methodology / non-animal alternative methods (NAMs) LAUS offers in vitro and in silico tests to provide human health hazard endpoints for skin or eye irritation and corrosion as well as skin sensitization.
  
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- Mutagenicity / Genotoxicity
  
  For genotoxicity and mutagenicity endpoints we offer a number of OECD studies on bacteria, mammalian cells and human lymphocytes. We support you with individual approaches that might be required for certain substances, e.g. nanomaterials.
  
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- Ecotoxicology
  
  In the area of aquatic and terrestrial ecotoxicology, LAUS carries out acute, subacute and reproduction studies. We are equipped with state-of-the-art technology for dose verification analysis, including nanomaterials.
  
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- Biodegradation / Environmental Fate
  
  The environmental fate of certain substances can be assessed by determining their biodegradability, their transformation or metabolism and their bioaccumulation potential.
  Biodegradability studies are also often used for eco-labels.
  
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- Analytical Chemistry
  
  LAUS analytical laboratories are not only equipped with the newest technology, which enables us to carry out analyses even in trace amounts, we also have experts with many years of expertise. We work according to SANTE and SANCO guidance. We develop and validate methods for the determination of content or concentration control for other studies.
  
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- Endocrine Properties
  
  The assessment of substances with endocrine activity becomes increasingly important in our regulatory framework. To be prepared for upcoming requirements, we already have some studies available, are in the process of establishing a number of key studies and have a network of partners to support you in a comprehensive way.
  
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- OR Service in the UK
  
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Biodegradation / Environmental Fate

Biodegradation / Environmental Fate

Biodegradation

The biodegradability is an important environmental parameter for the assessment of organic substances and describes its decomposition and mineralization by microorganisms in the environment. The OECD differs between the ready biodegradability and the inherent biodegradability. If the criteria of ready biodegradability are not reached, the inherent degradability should be tested in the next step. The OECD test methods are required for classification and approval of different product groups and are selected in dependence of the substance properties.

Thanks to many years of experience we can help you to develop an individual test strategy and to find the appropriate test method for your substance!

Ready Biodegradability
Guideline	Description	Substance properties
OECD 301A	DOC-Die-Away Test	water-soluble, not volatile
OECD 301B	CO₂-Evolution Test (Sturm Test)	water-soluble/water-insoluble, not volatile
OECD 301D	Closed-Bottle Test	water-soluble
OECD 301F	Manometric Respirometry Test	water-soluble/water-insoluble, volatile/not volatile
OECD 310	CO₂-Headspace Test	water-soluble

Inherent Biodegradability
Guideline	Description	Substance properties
OECD 302B	Zahn-Wellens / EMPA Test	water-soluble, not volatile, filterable

Anaerobic Biodegradability
Guideline	Description
OECD 311	Anaerobic Biodegradability of Organic Compounds in Digested Sludge: by Measurement of Gas Production

Biodegradability of Plastic Materials
Guideline	Description
EN ISO 14851:2019	Determination of the ultimate aerobic biodegradability of plastic materials in an aqueous medium - Method by measuring the oxygen demand in a closed respirometer (based on OECD 301F)
EN ISO 14852:2018	The endpoint Determination of the ultimate aerobic biodegradability of plastic materials in an aqueous medium - can be covered by EN ISO 14851

The study you need is not listed? Please contact us. We’ll prepare you an individual offer for your needs.