Mutagenicity and Genotoxicity

Testing of genotoxic and/or mutagenic effects is an important test category for many product groups and is therefore of high relevance. The tests in this field will be performed on bacteria and mammalian cells or human lymphocytes. Since a single test is not capable to detect all relevant genotoxic/mutagenic agents, the usual approach is to conduct a battery of tests of different focuses. Therefore the tests are separated in three different categories:

• Testing of gene mutations on bacteria
• Testing of numerical and/or structural chromosome aberrations (aneugenic and clastogenic effects) on mammalian cells/human lymphocytes
• Testing of gene mutations on mammalian cells

The selection of a suitable test systems often depends on the test substance as well as the regulatory requirements. We offer to develop an individual test protocol with you to address special properties of your substance or to meet specific requirements, for example, the exposure and proof of uptake into cells for the assessment of nanomaterials.

We would be pleased to advice you in this.