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27.09.2023

Genotoxicity testing of Nanomaterials calls for individual Approaches

For Genotoxicity testing of Nanomaterials there are specific requirements detailed in the REACH Appendix R7-1 for nanoforms:

  • the dispersion of the nanomaterial should be monitored to ensure that the cells are exposed to a sufficient effective dose under in vitro conditions
  • it is highly advised to verify the cellular uptake by appropriate methods

During the last months we have put a lot of thoughts and research into this topic. We have successfully developed an appropriate approach for our current projects.

As there is a huge diversity in nanomaterials, each test item calls for an individual experimental methodology. So if genotoxicity testing of nanomaterials is something you are concerned with, we would be more than happy to share our experience and discuss a specific strategy for you.

#LAUSgroup #genotoxicity #nanomaterials #REACH

https://www.laus.group/en/product-groups/chemicals/nanoparticles

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27.09.2023

LAUS helps funding the new refrigerated delivery vehicle of Tafel Edenkoben

The volunteers at Tafel Edenkoben (food bank) are doing great work supplying many people in need not only with food but also with furniture, clothes and toys. A new refrigerated delivery vehicle has been acquired in order to transport cooled goods. Funding was made possible by advertisements on the autobody. We at LAUS gladly support their work with an advertisement.

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12.09.2023

Among our newest equipment is a brand-new BBQ. Find out what else!

To the delight of our staff the latest addition to our technical equipment is a brand-new BBQ (on top of a GC-MS/MS and another LC-MS/MS, of course). Whereas the BBQ is for internal use only (and has been inaugurated already), the GC-MS/MS (Triple Quadrupole) and LC-MS/MS (Triple Quadrupole) are ready to use and waiting for new analytical challenges. If you have any analytical work on difficult substances to do, contact us to discuss our possibilities.

#LAUSgroup #BBQ #analytics #LCMSMS #GCMSMS #triplequadrupole

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23.05.2023

We use Human Blood for Genotoxicity Testing acc. to OECD 487

The Micronucleus Assay is an in vitro study to evaluate the mutagenicity/genotoxicity induced by chemical substances:

OECD 487 In Vitro Mammalian Cell Micronucleus Test

  • detection of micronuclei in the cytoplasm of interphase cells
  • test system: human lymphocytes freshly obtained by venipuncture

We have increased our capacities and can offer good timelines!

#LAUSgroup #mutagenicity #Moly #Micronucleus

https://www.laus.group/en/performance-profile/mutagenicity-genotoxicity

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15.05.2023

We believe that technology and sustainability go hand in hand

Our new LC-MS/MS (Waters Xevo TQ Absolute Triple Quadrupole) guarantees accurate results while reducing environmental impact. The system's reduced energy consumption and use of resources (synthetic air) make it a good choice for labs looking to minimize their carbon footprint. Paired with our highly qualified study directors this makes us a strong partner for your analytical work under GLP.

https://www.laus.group/en/performance-profile/analytical-chemistry

#LAUS.group #analyses #LCMSMS

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15.05.2023

Specific testing for Biocidal Spray Products

For Biocidal Spray Products we offer specific analyses in addition to the standard requirements for biocides:

  • spray pattern
  • internal pressure of spray cans
  • discharge rate
  • clogging

The tests could be integrated into stability studies such as shelf life, accelerated or cold storage.

#LAUSgroup #BPR #spray

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17.04.2023

Biodegradability: very good timelines!

At the moment LAUS can offer very good timelines for Biodegradability testing. Based on our extensive experience in this area we have streamlined our processes and increased our capacities. Contact us today!

https://www.laus.group/en/performance-profile/ecotoxicology/biodegradation

#LAUSgroup #Biodegradability #GLP #Biodegradation

 

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13.04.2023

LAUS testing ABC: M for “Moly” and “Micronucleus”

The Mouse Lymphoma Assay acc. to OECD 490 (short “Moly”) and the Micronucleus Assay acc. to OECD 487 are both in vitro studies to evaluate the mutagenicity/genotoxicity induced by chemical substances.

OECD 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene

  • detection of gene mutations
  • test system: mouse lymphocytes (L5178Y TK+/- clone (3.7.2C))

OECD 487: In Vitro Mammalian Cell Micronucleus Test

  • detection of micronuclei in the cytoplasm of interphase cells
  • test system: human lymphocytes freshly obtained by venipuncture

We have increased our capacities and can offer good timelines!

#LAUSgroup #mutagenicity #Moly #Micronucleus

https://www.laus.group/en/performance-profile/mutagenicity-genotoxicity

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08.02.2023

We Welcome Our New Team Members

We are more than happy to announce that we were able to fill 7 open positions with highly qualified personnel, both from intern and extern:

  • study directors in vitro toxicology (2)
  • study director ecotoxicology
  • technician analytical chemistry
  • technicians physico-chemistry (2)
  • technicians in vitro toxicology (2)
  • internship/master’s thesis ecotoxicology

They will strengthen our team starting in the first months of 2023. Welcome everyone!

#LAUSgroup #welcome

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04.01.2023

OECD 497: Defined Approaches (DAs) on Skin Sensitisation

OECD 497 provides Defined Approaches (DAs) for Skin Sensitisation assessment. It allows the Hazard Potential Identification (skin sensitiser / non-sensitiser) and GHS Classification into Potency subcategories 1A and 1B (H317) without animal tests.

Multiple information sources are taken into consideration to come to a conclusion:

In chemico test data (OECD 442C DPRA)

In vitro study data (OECD 442D KeratinoSens, OECD 442E h-CLAT)

In silico predictions (QSAR, DEREK Nexus)

Literature

Contact us for more information!

https://www.laus.group/en/performance-profile/toxicology/in-vitro-toxikologie

#LAUSgroup #OECD497 #invitrosensitisation #animalfree #NAM #skinsensitisation #H317

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04.01.2023

Health and Happyness for 2023!

An Automated External Defibrillator(AED) can save lives and it is much easier to use than you would expect. Since this is a matter close to our heart, in the context of the biannual safety check we had a briefing and demonstration of LAUS’ AED. Not only First Aiders could participate, but everyone interested was welcome to see how easy it could be operated. Luckily we yet have not had a situation where we needed it, but this training will hopefully encourage people to act where needed.

We hope you had a good start into the New Year and in this context we wish you Health and Happiness for 2023!

#LAUSgroup #AED #HappyNewYear

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