Octanol-Water Partition Coefficient (log P_ow)

GLP-Compliant log Pow Testing Services (OECD 117, 107, 123)

The determination of the Octanol-Water Partition Coefficient (log P_ow / log K_ow / log P / log D_ow) is a key requirement in regulatory toxicology, environmental risk assessment, and chemical registration in Europe and worldwide. The log P_ow value is the basis for evaluating the bioaccumulation potential.

LAUS offers

OECD 117: Partition Coefficient (n‑octanol/water), HPLC Method

-          HPLC Screening

-          for organic substances

-          covers log P_ow in the range of 0 to 6, can be expanded

-          suitable for UVCBs

OECD 107: Partition Coefficient (n‑octanol/water): Shake Flask Method

-          covers log P_ow values in the range of -2 to 4 (occasionally up to 5)

-          for organic substances

-          strictly applies to a pure substance

-          not suitable for surface-active materials

-          analytical determination required

OECD 123: Partition Coefficient (1‑Octanol/Water): Slow‑Stirring Method

-          for organic substances that do not display significant interfacial activity

-          if used for mixtures, the 1-octanol/water partition ratios determined are conditional

-          analytical determination required

Log Dow

-          for dissociating/ionisable compounds

-          ion-corrected logarithmic octanol-water partition coefficient for neutral molecules

-          determination acc. to OECD 117, OECD 107, OECD 123 possible

Ask us for customized experimental approaches for substances excluded by the guidelines.

Regulatory Importance of log P_ow

We generate GLP-compliant log P_OW data according to OECD 117, OECD 107, and OECD 123, for the following regulatory frameworks:

•    REACH regulation (EC No. 1907/2006) – Required for physicochemical characterization and environmental exposure assessment

 

•    CLP Regulation (Classification, Labelling and Packaging, Regulation (EC) No 1272/2008)– Supports hazard identification, including environmental classification

•    PBT/vPvB assessment – Log Kow is a key screening parameter for identifying substances with bioaccumulative properties

•    Environmental Risk Assessment (ERA) of Active Pharmaceutical Ingredients (APIs)–  (EMEA/CHMP/SWP/4447/00 Rev. 1- Corr.) –  Key parameter for decision tree

Supporting Your Regulatory Strategy

Our experts understand the regulatory landscape and select the most appropriate test method based on your substance properties and submission requirements. They help you generate robust log P_ow data that directly support the evaluation of bioaccumulation potential and environmental risk. By selecting the appropriate OECD method and ensuring GLP compliance, we help minimize regulatory risk, avoid costly delays, and ensure successful dossier acceptance.

Contact Us

Accurate and GLP-compliant data are crucial to avoid delays, additional testing, or rejection of submissions.

Contact us today to discuss your project and regulatory requirements.

 

Why Choose Our GLP Laboratory?

•    Full GLP compliance

•    Regulatory-ready reports suitable for global submissions

•    Proven experienced scientific staff

•    Scientifically sound study design aligned with regulatory expectations

•    GLP-certified log Pow laboratory in Europe