Modified Ames Test for Peptides and Amino Acid-containing Material

Do you have an amino acid-containing substance and need to evaluate its genotoxicity? The standard Ames Test (OECD 471: Bacterial Reverse Mutation Test) is not suitable for amino acid-containing material and could lead to false positive results. However, the Treat & Wash method is a modified procedure that allows testing of biological samples, test substances containing proteins, peptides and histidine itself. It involves washing the bacteria free of test compound after a 90 min exposure prior to plating out.

So, if this has been a challenge in the past, you might be happy to learn that LAUS offers this new modified bacterial mutation test to evaluate mutagenicity. Contact us for more information!

https://www.laus.group/en/mutagenicity-genotoxicity/

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